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KMID : 1155520160110020172
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Anesthesia and Pain Medicine
2016 Volume.11 No. 2 p.172 ~ p.175
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Multiple exposures of sevoflurane in a patient with hepatic damage from crushing injuries ?A case report?
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Kim Dong-Young
Cho Hyun-Chul
Park Sang-Yoong
Lee Ji-Hyeon
Lee Jong-Hwan
Chung Chan-Jong
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Abstract
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Sevoflurane, which has low solubility in blood, facilitates rapid induction and recovery. Sevoflurane is metabolized to hexafluoroisopropanol by cytochrome P450. Hexafluoroisopropanol has significantly less protein binding capability, does not accumulate and rapidly undergoes phase II biotransformation to form Hexafluoroisopropanol glucuronide, which is mostly excreted in the urine within 12 hours. Thus, the hepatotoxic potential of sevoflurane has been considered very low. However, there are many reports about hepatic toxicity after sevoflurane anesthesia. We report a case of a 21-year-old male who had high levels of aspartate transaminase and alanine transaminase with crushing injuries and had low hepatic dysfunction after 29 sevoflurane anesthesia treatments within three months.
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KEYWORD
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Hepatotoxicity, Sevoflurane
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